We have prepared a list of the main Contract Research Organizations (CROs) with offices in Italy and Spain as well as some useful information regarding those CROs.

We have also include our point of view and why you should choose Italy and Spain to conduct your clinical trial and which are the most interesting therapeutic areas.

We hope this is interesting for you and if any of the below information may have changed or is there any other CRO stablished in Italy and Spain, that is not listed, please don’t hesitate to contact us in order to include the information provided.

List of main CROs with offices in Italy and Spain:

Small and Midsize CROs with offices in Italy and Spain:


Contact information:


Location in Italy:

Leon Research

  • So, Corso Valdocco, 2 10122 Torino (Italy)

Locations in Spain:

Leon Research Headquarters

  • c/ Nicostrato Vela, s/n, M11.2 Parque Tecnológico de León 24009 León (Spain)

Leon Research- Madrid Offie

  • C/ San Emilio, 6 – Local 1 28017 Madrid (Spain)

Company size: 11 – 50 employees

Headquarters: León, Spain

Founded: 2007

Specialties: Early Phases Clinical Trials, Observational studies, Ophthalmology Clinical Studies, Phase III Clinical Trials, Food studies, Regulatory and EC approval, Pharma Outsourcing, Clinical studies monitoring, Data Management, Pharmacovigilance


Contact information:


Location in Italy:

  • Via Eleonora Duse, 53 00197 Rome (Italy)

Location in Spain:

Corporate Headquarters

  • Calle Gobelas 19, la Florida 28023 Madrid (Spain)

Company size: 50 – 200 employees

Headquarters: Madrid, Spain

Founded: 2001

Specialties: full-service CRO, IMPs, Medical devices, Diagnostics, Nutrition products.

Big size CROs with offices in Italy and Spain


Contact information:


Location in Italy:

OPIS SRL Headquarters

  • Via Matteotti, 10 20832 Desio – MB (Italy)

Location in Spain:

  • Avenida de Bruselas, 15 28108 Alcobendas – Madrid (Spain)

Company size: 200 – 500 employees

Headquarters: Desio, Monza Brianza (Italy)

Founded: 1998

Specialties: Clinical Research, CRO, Clinical Development, Early phase trials, Phase II and III studies, Post market studies, Observational research, Real world evidence studies, investigator initiated trials, medical device clinical investigations, nutraceutical studies, medical affairs and medical writing, Regulatory, Trials Start-Up, Data Management, Pharmacovigilance, Quality Assurance, e-Clinical Platform, Project Control, Statistical Analysis and Consultancy, Study Management and Monitoring, Preclinical and Drug Development Consultancy, and Training


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Contact information:


Location in Italy:

Clintec International S.R.L – Italy office

  • Via Properzio, 5 00193 Rome (Italy)

Locations in Spain:

Clintec International SL- Madrid Office

  • Paseo de la Castellana, 141 Planta 19 28046 Madrid (Spain)

Clintec International SL- Barcelona Office

  • Gran Via de Carles III, 84 Planta 3 Barcelona 08028 (Spain)

Company size: 500- 1.000 employees

Headquarters: Glasgow, Strathclyde (United Kingdom)

Founded: 1997

Specialties: Global clinical Insourcing/Resourcing, Clinical Research, Global Patient Recruitment, Clinical Manufacturing and Supplies, Top 5 Sponsors, Emerging Markets, Oncology, BioPharmaceuticals, Phase I-IV, Biotechnology, Rare Disease


Contact information:


Location in Italy:

Pharm-Olam International (Italia) S.R.L.

  • Piazza M. Buonarroti, 32 20145 Milano, Italy

Location in Spain:

Pharm-Olam International (Spain) SLU

  • Calle Antracita, 7, Floor 1 – Unit 6 Madrid, 28045 (Spain)

Company size: 500 – 1.000 employees

Headquarters: Houston, TX (United States)

Founded: 1994

Specialties: CRO, contract research, patient recruitment, regulatory, monitoring, data management, pharmacovigilance, phase, clinical trial, post-marketing surveillance, product registration, emerging markets, and patient reported outcomes


Contact information:


Location in Italy:

  • Via Antonio Vivaldi, 13 00043 Ciampino Rome (Italy)

Location in Spain:

  • Placa Catalunya, 1, Edifici TRIANGLE – 4ª Planta 08002 Barcelona (Spain)

Company size: 500- 1.000 employees

Headquarters: Carlsbad, CA (United States)

Founded: 1986Specialties: CRO, Life Sciences, Biotech, Oncology, Clinical Trial Services , CNS/Neuroscience, Rare and Orphan Disease, Pediatrics, Clinical Development Services, Ophthalmology, Immunotherapy, Phases I-IV, dermatology


Contact information:


Location in Italy:

Medpace Italy Srl

  • VIA OLONA n. 2 Milano, 20123 (Italy)

Location in Spain:

Medpace Spain

  • Calle Agustín de Foxa 29. 8° planta. Madrid, 28036 (Spain)

Company size: 1.000 – 5.000 employees

Headquarters: Cincinnati, OH (United States)

Founded: 1992

Specialties: Early Phase Clinical Research, Phase II-III Clinical Research, RWE-Late Phase Clinical Research, Medical Device and Diagnostics, Regulatory Affairs, Medical Writing, Clinical Monitoring, Clinical Trial Management, Biostatistics and Data Sciences, Drug Safety and Pharmacovigilance, Quality Assurance, Central Laboratories, Bioanalytical Laboratories, Imaging & ECG Core Labs


Contact information:


Location in Italy:

  • Via Indipendenza 11 Calco (Lecco) 23885 (Italy)

Location in Spain:

  • Ave Via Augusta 15-25 B2 Sant Cugat del Valles, Barcelona (Spain)

Company size: More than 10.000 employees

Headquarters: Wilmington, Massachusetts (United States)

Founded: 1947

Specialties: Research Models & Services, Preclinical Services, Discovery Research Services, Biologics Testing Solutions, Microbial Identificiation, Endotoxin Testing, LAL, Early Discovery, Safety Testing, Agrochemical


Contact information:


Locations in Italy:

Covance Clinical and Periapproval Services Ltd – Filiale Italianac/o

  • Regus Business Centre Via Luca Gaurico 9/11 00143 Rome (Italy)

Covance, Inc.

  • Via Montecuccoli 20/1 20147 Milan (Italy)

Location in Spain:

Covance Clinical and Periapproval Services SA – Sucursal en Espana Covance Clinical Development S.A.,

  • Parque Empresarial Las Tablas, Calle Federico Mompou, 5, Edificio 1, 5ª planta, 28050 Madrid (Spain)

Company size: More than 10.000 employees

Headquarters: Princeton, New Jersey (United States)

Founded: 1996

Specialties: Drug Development Services, Toxicology Services, Central Laboratory Services, Clinical Trial Management Services, Clinical Research, Phase I-IIa, Phase II-III, Preclinical Solutions, Cardiovascular, Oncology, Market Access, Rare Disease, Orphan Drugs, Biotech, Pharmaceuticals, Crop Protection, Clinical Trial Optimization, Market Access, Clinical Trials, Biologics, Cell and Gene Therapy, Pharmacovigilance, NASH, Infectious Diseases, Drug Testing, CRO, Immuno-Oncology, Commercialization, Pediatrics, Kidney Disease, Inflammation, Life Sciences, Bioassays, Bioanalysis, Biologics, Large Molecule, Small Molecule


Contact information:


Locations in Italy:

  • Via Cornelio Magni 15, 7th Floor Roma, 00147 (Italy)
  • Via Benigno Crespi, 19 – MAC3 Milan (Italy)

Locations in Spain:

  • Calle de Cantabria, 2 – 3ra. planta – Módulo B2, Edificio Amura Alcobendas Madrid, 28108 (Spain)
  • Torre Diagonal Mar, C/ Josep Pla Nº 2, Planta 11 Mod A1 08019 Barcelona (Spain)

Company size: More than 10.000 employees

Headquarters: Dublin (Ireland)

Founded: 1990

Specialties: Medical Device, Therapeutics, Government and Public Health Solutions, Clinical Research Services, Commercialisation and Outcomes, Oncology, Value Based Healthcare, Clinical Trials, Patient Recruitment, Innovation, Regulatory Affairs, Strategic Consulting, Medical Affairs, Global Patient Insights & Engagement


Contact information:


Location in Italy:

  • Via Fabio Filzi 29 20124 Milano (Italy)

Locations in Spain:

  • C/Juan Esplandiú 11-6ª 28007, Madrid (Spain)
  • C/ Provença 392-3ª 08025, Barcelona (Spain)
  • C/ Paseo de Gracia, 49 Planta 3 08007, Barcelona (Spain)

Company size: More than 10.000 employees

Headquarters: Danbury, CT and Durham, NC (United States)

Founded: 2016

Specialties: Clinical Development, Biopharma


Contact information:


Location in Italy:

Parexel international

  • Via Filippo turati, 28 Milan, 20121 (Italy)

Location in Spain:

Parexel international, S.L. Edificio Sollube

  • Plaza de Carlos Trías Beltrán, 7 – 7ª planta Madrid, 28020 (Spain)

Company size: More than 10.000 employees

Headquarters: Newton, Massachusetts (United States)

Founded: 1982

Specialties: Regulatory and product development consulting, early phase clinical research, phase II-III clinical research, late phase clinical research, eClinical solutions, patient and site recruitment, medical device consulting, clinical research organization, pharmacovigilance, biotechnology, biotech, market access


Contact information:


Location in Italy:

  • Segreen Business Park Palazzo Y, via san Bovio 3 San Felice Segrate, Milan 20090 (Italy)

Locations in Spain:

  • Torre Nozar Titán, 15 6th Floor Madrid, 28045 (Spain)

Company size: More than 10.000 employees

Headquarters: Wilmington, NC (United States)

Founded: 1985

Specialties: clinical research, drug development, CRO, patient recruitment, laboratory, pharmaceutical, biotechnology, biopharma, biopharmaceutical, consulting, therapeutics, Functional Service Partnerships, consulting, Early Development, Post-Approval


Contact information:


Location in Italy:

  • Via Vittor Pisani 14, 3a Planta Milan 20124 (Italy)

Locations in Spain:

  • Avda. Europa, 19 – Edif. 1 – 3a Planta 28224, Pozuelo de Alarcon, Madrid (Spain)
  • Diagonal 210, 4th Floor Barcelona 08018 (Spain)

Company size: More than 10.000 employees

Headquarters: Raleigh, North Carolina (United States)

Founded: 1976

Specialties: Clinical Research, Phase I-IIa, Phase II-III, Post Approval, Safety & Risk Management, Therapeutic Expertise, Biosimilars, Bioanalytical Laboratories, Rare Disease, Oncology, Immunology, Infectious Disease, Neuroscience, Pain, Pediatrics, Vaccines, Data & Techology Solutions, Early Development Services, Laboratory Solutions, Real World Solutions, Clinical Development, Product Registration, Respiratory, Cardio-metabolic


Contact information:


Locations in Italy:

  • Via Gonzaga 7 Milan, 201123 (Italy)
  • Vicolo del Caldo, 36 21047 Saronno (VA) (Italy)

Locations in Spain:

  • Pau Claris 194-196 5th Floor Corsega, 340-342 08037 Barcelona (Spain)
  • Avda. Diagonal 601 (6A) Barcelona, 08028 (Spain)
  • Floor 3/2, Calle Hernani 59 Madrid, 28020 (Spain)
  • C/Rosa De Lima 1 BIS, Edificio Alba, 2a planta Las Matas, Madrid, 28290 (Spain)

Company size: More than 10.000 employees

Headquarters: Morrisville, NC (United States)

Founded: 2017

Specialties: CRO, Clinical Trials, Commercialization

Main reasons to choose Italy and Spain to conduct your clinical trial

Italian and Spanish economy: Italy is the 3rd largest national economy in the European Union, and Spain is situated in the 6th position.

Good health system: According to a World Health Organization ranking where they measured health systems, France provides the best overall health care followed by Italy and Spain.

Professionalism: Both countries count with committed and highly qualified personnel.

Population: Italy has 60.5 million inhabitants and Spain 47 million.

High quality Research Centers and Universities: which are really prestigious all over the world

Recruitment rates: The recruitment rate is high in both countries being Italy slightly bigger than Spain.

Approval submission timelines: Both countries are working on reducing the time on regulatory affairs.

Contract Negotiation: Regarding the contract negotiation, in both cases can be negotiated while obtaining the approval, and most sites have their own contract template, usually in local language and in English

Regulatory affair timelines leon research

Most interesting therapeutic areas to conduct your clinical study in Italy and Spain

According to our experience in both countries and as the life expectancy is very high (82 years old in Italy and 83 years old in Spain), there are many trials that study age related diseases such as: ophthalmology, Central Nervous System, diabetes, etc.

Other therapeutic areas with high incidence in the population in Italy and Spain are the sun related diseases such as skin cancer and other dermatology diseases.



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